The next CABS conference will be held

May 4-6, 2017

in Indianapolis, Indiana

REGISTER NOW FOR THE 2017 CABS CONFERENCE

  • JOIN us may 4-6, 2017 in indianapolis, INdiana for the next CABS conference!

  • REGISTRATION IS OPEN! See BELOW FOR REGISTRATION PRICING AND DETAILS.


ABSTRACTs & REGISTRATIOn

Abstracts

Please join us for the next Cancer and Bone Society meeting, which will be held May 4-6, 2017 in Indianapolis, Indiana! Abstract submission is now closed. Authors will be contacted in April regarding selection of abstracts for a poster or oral presentation. Please contact Julie Sterling at julie.sterling@vanderbilt.edu with any questions, and we look forward to seeing you in Indiana!

Registration

REGISTER NOW!

Conference registration is now open! Registration will include access to all conference functions as well as a wine and cheese reception Thursday evening, breakfast and lunch on Friday, coffee breaks, and breakfast on Saturday. Remember to join CABS to receive discounted registration rates! Rates through May 4th, 2017 are as follows:

CABS Member Trainee $200

CABS Member $300

Non-members $400

Continuing medical education (CME) is available for physicians.


Conference information & Logistics

Venue

The CABS conference will be held at the Sheraton Indianapolis Hotel at Keystone Crossing. The Sheraton Indianapolis Hotel at Keystone Crossing is located on the north side of Indianapolis in the city's most affluent area, Keystone at the Crossing, and is attached to the Fashion Mall.

The hotel is just a short drive to both downtown Indianapolis and the Indianapolis International Airport (IND). Enjoy complimentary self-parking, indoor swimming pool, fitness center, and more great hotel features during your stay. The Sheraton is also providing complimentary wi-fi service for the CABS room block!

Address: View in Google Maps

8787 Keystone Crossing

Indianapolis, IN 46240 USA

Hotel Rooms

Attendees should make their reservations to stay at the Sheraton either through the special online link https://www.starwoodmeeting.com/Book/CABS or by calling 1-888-627-7814. Individuals should identify themselves as attending the Cancer and Bone Society Conference (CABS Conference) at time of registration and provide a valid credit card to guarantee the reservation. The discounted nightly rate is $169 per night if booked by April 11 and is for the nights of 5/4 and 5/5 only. If additional nights are needed outside of those dates before or after the conference, please contact Erin Simon directly at 317-574-6744 to make your reservations and mention that you are with the Cancer and Bone Society Conference.

Cancellations: Individuals will be charged for one night’s room and tax if they do not cancel their reservation within 72 hours prior to scheduled arrival. An additional $75 service fee will be charged should an attendee check out prior to the confirmed checkout date. The hotel will not guarantee the $169 rate beyond the April 11, 2017, so make your reservations today!

Travel

Indianapolis International Airport (IND) is the closest airport to the Sheraton Indianapolis Hotel at Keystone Crossing and is approximately 30 minutes away. Transportation to / from the airport is by taxi.

For those who wish to head to downtown Indianapolis, most activities downtown center around Monument Circle, which is approximately 30 minutes away in the heart of Indianapolis. There is paid parking available around downtown, and once you park, you can walk to many restaurants and activities. A map of downtown, including Monument Circle, is available here.


Scientific program

Our proposed Cancer and Bone scientific program will present the most recent cutting edge advances in cancer-induced bone disease research and provide an important venue for established and young investigators to network and present their newest research.

Session topics will include:

  • Tumor Dormancy
  • Skeletal Effects of Cancer in Bone
  • Fat Cells, Adipokines, and Metabolism
  • New Models for Cancer and Bone / Bone Biomechanics
  • Genomics and Immunoncology of Bone Metastases (clinical focus)
  • New Therapeutic Approaches in the Clinical Management of Cancer in Bone (clinical focus)

UPDATED PRELIMINARY PROGRAM AVAILABLE FOR DOWNLOAD!


PRELIMINARY PROGRAM (Updated!):

Thursday, May 4, 2017

I. Young Investigator Networking Session (4:00pm to 5:30pm)

Session Chairs: Patricia Juarez and Rachelle Johnson

"How to network at scientific meetings" presented by Julie Sterling and followed by opportunities to network with investigators of all stages.

CABS attendees at all career stages are invited and encouraged to attend!

II. Welcome Reception and Poster Session I (5:30pm to 7:20pm)

Poster Session I (6:00-7:00pm) : Posters #1-31 ONLY


Friday, May 5, 2017

I. Welcome (8:00am to 8:30 am)

II. Tumor Dormancy (8:30am - 10:10am)

Session Chairs: Peter Croucher and Penelope Ottewell

8:30 – 8:55am : Sheila Stewart (Washington University)

"Age-related changes in the bone drive metastasis"

8:55 - 9:20am : Michelle McDonald (Garvan Institute)

"Investigating interactions between tumour cells and the bone microenvironment"

9:20 - 9:45am : Rachelle Johnson (Vanderbilt University)

"Hypoxia in tumor dormancy and bone metastatic disease"

9:45 - 10:10am : Young Investigator Presentations

"RANKL-induced bone remodelling controls prostate cancer cell dormancy in an ex vivo calvaria model" Niall Byrne (Garvan Institute)

"Epigenetic regulation of the LIFR and its role in breast cancer dormancy" Miranda Sowder (Vanderbilt University)

"Single-cell RNA sequencing of dormant myeloma cells identifies new therapeutic targets" Weng Hua Khoo (Garvan Institute)

_______________________________________

10:10 - 10:30am : Coffee and open discussion

_______________________________________

III. Skeletal Effects of Cancer in Bone (10:30 - 12:10pm)

Session Chairs: Toshio Matsumoto and Patricia Juarez

10:30 - 10:55am : Evan Keller (University of Michigan)

"Osteocytes in prostate cancer bone metastasis"

10:55 - 11:20am : Stavroula Kousteni (Columbia University)

"Genetic control of the bone marrow niche in Acute Myeloid Leukemia"

11:20 - 11:45am : Penelope Ottewell (University of Sheffield)

"Model systems of human breast cancer metastasis to human bone predict new biomarkers and therapeutic targets"

11:45 - 12:10pm : Young Investigator Presentations

"Novel Cytoplasmic Functions of the Vitamin D Receptor in Breast and Prostate Cancer" Trupti Trivedi (University of Sydney)

"MMP Processing of PTHrP Yields a Selective Regulator of Osteogenesis, PTHrP1-17" Jeremy Frieling (Moffitt)

"In vitro and in vivo evidence that RANK/RANKL promotes early breast cancer dissemination to the bone marrow" Sofia Sousa (INSERM)

_______________________________________

12:10 - 1:30pm : Lunch and Poster Session II

Poster Session II (12:30-1:30pm) : Posters #32-61 ONLY

_______________________________________

IV. Fat Cells, Adipokines, and Metabolism (1:30 - 3:10pm)

Session Chairs: Florent Elefteriou and Laura Wright

1:30 - 1:55pm : Claire Edwards (University of Oxford)

"Adipokines and adiposity in myeloma bone disease"

1:55 - 2:20pm : Izabela Podgorski (Wayne State University)

"Functional contribution of marrow adipocytes to tumor survival pathways in bone"

2:20 - 2:45pm : Michaela Reagan (University of Maine/Tufts)

"Bone marrow adipose tissue and multiple myeloma"

2:45 - 3:10pm : Young Investigator Presentations

"Modified Herpes Simplex Virus (HSV1716 (SEPREHVIR)) induces potent myeloma onocoylis in vitro and in vivo and prevents cell line regrowth" Simon Tazzyman (Sheffield)

"Multiple myeloma regulates bone marrow adipocyte number, localisation and adipokine secretion" Emma Morris (Oxford)

"Decreased JMJD3 Expression in Mesenchymal Stem Cells Contributes to Long-term Suppression of Osteoblast Differentiation in Multiple Myeloma" Wei Zhao (IUSM)

______________________________________

3:10 - 3:30pm : Coffee and open discussion

______________________________________

V. Other cells affecting tumor growth in bone and bone pain (3:30 - 5:10pm)

Session Chairs: David Roodman and Theresa Guise

3:30 - 3:55pm : Toshiyuki Yoneda (IUPUI)

"Cross-talk between breast cancer cells and sensory nerves in bone"

3:55 - 4:20pm : Roberta Faccio (Washington University)

"Immunesuppressive role of Dkk1 in cancer via regulation of myeloid suppressor cells"

4:20 - 4:45pm : Jesus Delgado-Calle (IUPUI)

"Role of osteocytes in multiple myeloma induced bone disease"

4:45 - 5:10pm : Young Investigator Presentations

"A novel osteolinage-derived cancer-associated fibroblast population in primary tumors expresses DKK1 and enhances tumor growth" Biancamaria Ricci (Washington University)

"Sympathetic Activation Alters the Bone Vasculature: Implication for Osteotropic Breast Cancer Metastasis" Patrick Mulcrone (Vanderbilt University)

"Targeting bone pain: Multiple myeloma increases nociceptive markers through interactions with the bone microenvironment" Sam Olechnowicz (Oxford)

______________________________________

5:10 - 5:30pm : Break

______________________________________

VI. New Models for Cancer in Bone / Bone Biomechanics (5:30 - 7:10pm)

Session Chairs: Alex Robling and Maureen Lynch

5:30 - 5:55pm : Julie Sterling (Vanderbilt University)

"3D Bone models to study the complex physical and cellular interactions between tumor and the bone microenvironment"

5:55 - 6:20pm : Sarah Amend (Johns Hopkins University)

"Revisiting seed and soil: the "cancer swamp" promotes the lethal phenotype"

6:20 - 6:45pm : Jeffry Nyman (Vanderbilt University)

"Role of biomechanics in tumor-induced bone disease"

6:45 - 7:10pm : Young Investigator Presentations

"3D in vitro Bone-templated Model of Tumor-induced Bone Disease" Joseph Vanderburgh (Vanderbilt University)

"Bone-induced expression of integrin β3 on breast cancer metastases enables targeted nanotherapy" Michael Ross (Washington University)

"Delivery of Nanoparticle-Encapsulated Gli Inhibitor Blocks Tumor-Induced Bone Disease" Kristin Kwakwa (Vanderbilt University)


Saturday, May 6, 2017

I. Genomics and Immunoncology of Bone Metastases (Clinical focus) (8:00-9:40am)

Session Chairs: Kathy Weilbaecher and Philippe Clezardin

8:00 - 8:25am : Madhav Dhodapkar (Yale)

"Insights from new humanized models to study tumor-host interface"

8:25 - 8:50am : Gary Stein (University of Vermont)

"The architecturally dynamic genetic and epigenetic landscape of cancer biology and pathology"

8:50 - 9:15am : Carl Walkley (St. Vincent's Institute)

"Development and application of murine models of osteosarcoma for preclinical target discovery and validation"

9:15 - 9:40am : Young Investigator Presentations

"HTLV-1 Viral Oncogene HBZ Induces Lymphoproliferative and Osteolytic Bone Disease in Transgenic and Humanized Mouse Models" Jingyu Xiang (Washington University)

"TGF-β’s Role in Myeloid Regulation of Tumor-Induced Bone Disease (TIBD)" Denise Buenrostro (Vanderbilt University)

"HDAC inhibition: A novel therapeutic approach for the treatment of primary and lung metastatic osteosarcoma" Jeremy McGuire (Moffitt)

________________________________________

9:40 - 10:00am : Coffee and open discussion

________________________________________

II. New therapeutic approaches in the clinical management of Cancer in Bone (10:00 - 11:45am)

Session Chairs: Cathy van Poznak and Rebecca Silbermann

10:00 - 10:30am : Rob Coleman (University of Sheffield)

"Clinical advances in prevention and treatment of bone metastases"

10:30 - 11:00am : Noopur Raje (Harvard)

"Biology and treatment of myeloma related bone disease"

11:00 - 11:30am : Lianping Xing (University of Rochester)

"Development of novel bone targeted Bortezomib to treat multiple myeloma"

11:30 - 11:45am : Young Investigator Presentations

"CaMKK2 Inhibition as a “Dual-Hit” Strategy against ADT-Induced Osteoporosis and Bone-Metastatic Prostate Cancer" Ushashi Dudwal (IUSM)

"Dual BET domain-kinase Inhibitors for the treatment of Multiple Myeloma" Marilena Tauro (Moffitt)


FUTURE CONFERENCES:

We are excited to announce that the 2018 CABS Conference will be held in conjunction with the 8th Annual MolPharm Workshop June 30th - July 3rd, 2018 in Oxford, UK! Click here for the official announcement, and visit the MolPharm website for more information: http://www.molpharmworkshop.org. We will post additional details to the CABS website following our 2017 meeting in Indianapolis.


Past Conferences:

2016 CABS-ECTS Conference (May 14-15, Rome, ITALY)